No gut no gain! Enteral bile acid treatment preserves gut growth but not parenteral nutrition associated-liver injury in a novel extensive short bowel animal model

Identification: JPEN181101
Credits (Post Test and/or Evaluation Required)
Available until 11/30/2019
  • 1.00 - Dietitian
  • 1.00 - Nurse
  • 1.00 - Pharmacist
  • 1.00 - Physician
  • 1.00 - Other


*To take the exam click the CE Information tab*

CE Credit:  CE credit available for dietitians, nurses, pharmacists and physicians

Total Credit Hours:  1.0

Release Date: November 1, 2018

Expiration Date (all CE credit must be claimed by the expiration date):  November 30, 2019

Issue: 8

Volume: 42

Journal:  Journal of Parenteral and Enteral Nutrition (JPEN)

Author (s):

Gustavo Villalona, MD, Director of Outcomes Research, Pediatric Surgery, Cardinal Glennon Children's Hospital, Saint Louis, MO

Amber Price, BS, Research Lab Assistant, Coldstream Laboratories, INC, Lexington, KY

Keith Blomenkamp, BA, Senior Research Assistant, Saint Louis University Med. School, Saint Louis, MO

Chandrashekhara Manithody, PhD, Research Faculty, Pediatric Department, St. Louis University, Saint Louis, MO

Saurabh Saxena, MD, Senior Research Fellow, Cardinal Glennon Children's Hospital, Department of Pediatric Surgery, St. Louis, MO

Thomas  Ratchford, MD, Pediatric Gastroenterology Fellowship, Saint Louis University, Saint Louis, MO

Matthew Westrich, BS, Student, Saint Louis University, Saint Louis, MO

Vindhya Kakarla,  MBBS, Research Intern, Saint Louis University, Saint Louis, MO

Shruthika Pochampally, BS, Research Assistant, Saint Louis University Department of Pediatrics, Saint Louis, MO

William   Phillips, BS, Scribe, ScribeAmerica, Washington University School of Medicine, Division of Dermatology, Saint Louis, MO

Nicole Heafner, BS, Student,Creighton University School of Medicine, Omaha, NE;

Niraja Korremla, MBBS, Resident, Saint Louis University Hospital, Saint Louis, MO

Jose Greenspon, MD, Assistant Professor of Surgery, Saint Louis University School of Medicine, Saint Louis, MO

Miguel Guzman, MD, Assistant Professor of Pathology, Assistant Professor of Neurology, Director of Pediatric Pathology Fellowship, Saint Louis University, School of Medicine, Saint Louis, MO

Ajay Kumar Jain, MD, Associate Professor, Tenured, Chairman for Nutritional Advisory Committee, Medical Director of Pediatric Liver Transplantation, Saint Louis University, Saint Louis, MO.

Link to article: Link

Journal-based CE Activity Overall Goal:

The JPEN Editor, in concurrence with ASPEN’s Education and Professional Development Committee, selected this article to be offered for CE credit to fill an observed learning need in the arena of clinical nutrition and metabolism.  This CE activity serves to promote the process of life-long learning for physicians, dietitians, pharmacists, and nurses by providing peer-reviewed journal articles that fully qualify for continuing education credits.

Goal and Target Audience:

This educational activity is directed toward clinical nutrition and metabolism professionals and others who wish to update their knowledge of clinical nutrition and metabolism. By participating in this educational activity, the reader may expect to:

  • Acquire knowledge in the area of clinical nutrition and metabolism research
  • Update or confirm your understanding of appropriate clinical nutrition and metabolism practices.
  • Identify further learning needs as they relate to the subject matter.

Learning Objectives:

  1. Summarize the etiology of parenteral nutrition associated injury as driven by a lack of gut derived signaling
  2. Evaluate the divergent pathways driving liver and gut injury with parenteral nutrition
  3. List and describe the key receptors, transporters, and regulators involved in the gut-liver cross talk
  4. Identify the implications of extensive bowel resection on the gut-liver signaling
  5. Describe the limitation of large animals studies and their applicability to human patients
  6. Define the implications of using luminal receptor agonist therapy in the setting of extensive small bowel resection   

Requirements for Successful Completion:
To obtain CE credit for this activity, attendees must read the journal article in its entirety, complete an online knowledge assessment for each article and complete an online activity evaluation. All CE credit must be claimed prior to the expiration date.    

Accreditation Statements/Continuing Education Credit

Nurses, Pharmacists and Physicians

In support of improving patient care, The American Society for Parenteral and Enteral Nutrition (ASPEN) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

This activity is for a maximum of 1 contact hour (0.1 CEU) per journal article and is a knowledge activity. 

ASPEN designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credits TM per article. Physicians should only claim credit commensurate with the extent of their participation in the activity.

ASPEN is approved by the California Board of Registered Nursing, Provider CEP 3970.

ACPE UAN: JA0002345-0000-18-077-H01-P
Knowledge activity. 


ASPEN, Provider Number AM005, is a Continuing Professional Education (CPE) Accredited Provider with the Commission on Dietetic Registration (CDR).   CDR level 2.  Dietitians may post comments on this program on


Non-Commercialism:  ASPEN subscribes to the ACCME Standards for Commercial Support.  ASPEN does not provide programs that constitute advertisement or include promotional materials.  ASPEN does not endorse any products. 

Computer Requirements and Technical Support:  Participants will need a computer with internet connection to access the online assessment and evaluation for each journal article.  If the journal article is read electronically, then the ability to read a PDF document is also necessary.  Users should enable pop-ups if attempting to read article electronically.  For technical difficulties please contact Digitell Inc. Customer Support at: 1-800-679-3646

Office hours are between 9AM to 5PM ET, Monday through Friday

Privacy and Confidentiality:  ASPEN respects the privacy of its members and website visitors. Companies that receive personal information from ASPEN in order to execute the business of ASPEN may use personal information only for that purpose.

Refund Policy: Refunds are not available. 

Grievances:  Grievances must be submitted in writing to Director of Education at ASPEN 8401 Colesville Road, Suite 510, Silver Spring, MD 20910.

Commercial Support and Sponsorship:
No commercial support or sponsorship has been received for this continuing education activity.

Commercial Relationships Disclosures and Conflicts of Interest (COI) of Authors and Editor-in-Chief and Associate Editors

Among the authors, Adam McCulloch, Vishakha Bansiya, and Jeremy Woodward have nothing to disclose.

Among the JPEN Associate Editors, David August, Ronald Koretz, Ding-You Li, Jean-Charles Preiser, and Diana Mager have nothing to disclose.

Lillian Harvey-Banchik has served on the speaker’s bureau for MEI communications and received compensation per talk given. 

JPEN Editor-in-Chief Kelly Tappenden has served in speaking and teaching roles for Shire, Nutricia, and Abbott Nutrition. Has received honoraria for those roles.

No conflicts related to disclosure information present and subsequently no need for resolution. Standard journal peer-review process also in place as another layer of review to ensure no conflicts to resolve.

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Credits: None available.