M10 - Dudrick Research Symposium: The Hidden (Gut) Dysfunction in Sepsis (M10)

The 2022 Dudrick Research Symposium: The Hidden (Gut) Dysfunction in Sepsis, has been planned by the 2021 Stanley J. Dudrick Research Scholar Award winner, Jayshil Patel, MD, Associate Professor of Medicine, Division of Pulmonary and Critical Care Medicine, Medical College of Wisconsin, Milwaukee, WI.

Sepsis is hallmarked by organ dysfunction secondary to an infection. While other organ dysfunctions are more evident, gut dysfunction is often hidden and difficult to ascertain in sepsis, but important to acknowledge since gut dysfunction has the capacity to incite and sustain extra-intestinal organ failure. This program will shed light on key drivers of gut dysfunction in sepsis, implications for extra-intestinal organ dysfunction, and identify novel nutritional strategies to attenuate gut-derived inflammation and its impact on extra intestinal organs.

LEARNING OBJECTIVES

1. Explain how intact intestinal barrier function and homeostatic signaling with a commensal microbiome support appropriate and robust cellular and humoral immune responses
2. Summarize how the oxidative stress of pathophysiologic processes such as sepsis, pancreatitis, and COVID-19 lead to breakdown of barrier defenses and progression to dysbiosis, immune dysregulation, and emergence of a virulent pathobiome
3. Describe multiple mechanisms by which the gut microbiome may contribute to the pathogenesis of multiple organ failure in critically ill patients
4. Discuss how common ICU interventions alter the lower gut ecosystem, potentially influencing the gut microbiome’s role in the pathogenesis of multiple organ failure
5. Explain the historical rationale used to justify providing sterile, chemically defined, fiber free liquid diets to critically ill patients
6. Describe the role of emerging technology in microbiome sciences (sequencing, metabolomics) in defining the adequacy/inadequacy of current methods of feeding critically ill patients

FACULTY AND TOPICS
Beyond Translocation: Gut Barrier Function in Sepsis
Stephen McClave, MD, FACN, FASGE, FASPEN, AGAF, Professor of Medicine, Division of Gastroenterology and Hepatology; Director of Clinical Nutrition, University of Louisville School of Medicine, Louisville, KY

Beyond the Gut: The Relationship Between Gut Dysfunction and Extraintestinal Organ Injury
Robert Dickson, MD, Associate Professor of Medicine, Division of Pulmonary & Critical Care Medicine, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI

Nutrition and Beyond: Diet and Novel Therapies to Preserve Gut Barrier Function in Sepsis
John Alverdy, MD, FACS, Sarah and Harold Lincoln Thompson Professor of Surgery; Executive Vice Chair, Department of Surgery, University of Chicago Pritzker School of Medicine, Chicago, IL

MODERATOR
Jayshil Patel, MD, Associate Professor of Medicine, Division of Pulmonary and Critical Care Medicine, Medical College of Wisconsin, Milwaukee, WI

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