Liam McKeever PhD, RDN, FASPEN

ASPEN Clinical Guidelines Director; Postdoctoral Fellow, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

Dr. McKeever is a clinical nutritional epidemiologist and postdoctoral fellow with the Penn Center for Nutrition Science and Medicine at the University of Pennsylvania. His research interests center on uncovering the nuanced consequences of nutrition support in critical illness. He addresses this by postulating and testing mechanisms of harm in feeding patients and determining the impact of genotype on these processes. Although many large ICU studies have explored the relationship between feeding and clinical outcomes, their findings have only ever provided a population average effect. Some of these studies demonstrate feeding to be harmful, some helpful and some benign. However, none are designed to address the likely possibility that patients respond differently to nutrition support according to their disease status and genetic make-up. In his doctoral work, he demonstrated that critical care nutrition may increase oxidative stress alone and in the context of two single nucleotide polymorphisms relevant to nutrition-induced hydrogen peroxide clearance. His future work focuses on other genetic polymorphisms that may modify the effect of nutrition on clinical outcome.