Obesity is a global health problem and ameliorative strategies remain a major research focus. Although several interventions have been trialed, the mainstay of current therapy anchors on lifestyle modification inclusive of nutrition and exercise. Primary criticisms of the current treatment modalities

Objectives:

Summarize the current literature exploring the role of gut derived signals in modulating disease pathology in the context of Gastric Bypass
Identify the role of bile acids as signaling molecules mediating the Gut-Liver crosstalk as well as the role of the gut microbiota and metabolic signaling secondary to nutrient intake in the context of Gastric Bypass
Describe the strengths and limitations of the existing literature and identify directions and designs for new clinical translational and basic research
Evaluate clinically relevant, and cutting-edge research, on the mechanisms by which gut derived signals modulate outcomes post bariatric surgery

Carel Le Roux PhD, MSc, MBChB, FRCP, FRC Path

Professor, Head of Pathology, Chair of Experimental Pathology, University College Dublin, School of Medicine and Medical Science, Dublin, Ireland

Appearances