Topiramate treatment of pediatric metabolic dysfunction-associated steatotic liver disease: A descriptive cohort study
Read the full article and take the exam for CE credit. This CE activity serves to promote the process of life-long learning for physicians, dietitians, pharmacists, and nurses by providing peer-reviewed journal articles that fully qualify for continuing education credits.
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1 Dietitian | 1 Nurse | 1 Pharmacist | 1 Physician | 1 Other | Available until March 31, 2026
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Activity Instructions: Read the full article and take the exam by clicking the "CE Information" tab.
CE Credit: CE credit available for dietitians, nurses, pharmacists and physicians
Total Credit Hours: 1.0
Release Date: April 1, 2025
Expiration Date (all CE credit must be claimed by the expiration date): March 31, 2026
Issue: 3
Volume: 49
Journal:Journal of Parenteral and Enteral Nutrition (JPEN)
Author (s):
Taisa Kohut, MD, Assistant Professor, Pediatric Gastroenterology, Hepatology and Nutrition, University of Miami Miller School of Medicine, Jackson Memorial Hospital, Miami, FL
Andrea Tou, MD, Fellow, Pediatric Gastroenterology, Children’s Hospital of Philadelphia, Philadelphia, PA
Emily Carr, MD, MPH, Practice Manager, Connecticut OCD, Anxiety, and Tic Specialists; Research Coordinator, Department of Pediatric Gastroenterology and Liver Transplant, Yale University School of Medicine, New Haven, CT
Stavra Xanthakos, MD, MS, Professor of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Ana Catalina Arce-Clachar, MD, Associate Professor of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Rima Fawaz, MD, Associate Professor, Department of Pediatrics, Section of Gastroenterology and Hepatology, Yale School of Medicine, New Haven, CT
Pamela L. Valentino, MD, MSc, Associate Professor of Pediatrics, Department of Pediatrics, University of Washington, Seattle, WA
Jennifer Panganiban, MD, Associate Professor of Clinical Pediatrics (Gastroenterology, Hepatology, and Nutrition), University of Pennsylvania School of Medicine, Philadelphia, PA
Marialena Mouzaki, MD, MSc, Staff Physician, Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Journal-based CE Activity Overall Goal: The JPEN Editor, in concurrence with ASPEN’s Education and Professional Development Committee, selected this article to be offered for CE credit to fill an observed learning need in the arena of clinical nutrition and metabolism. This CE activity serves to promote the process of life-long learning for physicians, dietitians, pharmacists, and nurses by providing peer-reviewed journal articles that fully qualify for continuing education credits.
Goal and Target Audience: This educational activity is directed toward clinical nutrition and metabolism professionals and others who wish to update their knowledge of clinical nutrition and metabolism. By participating in this educational activity, the reader may expect to:
Acquire knowledge in the area of clinical nutrition and metabolism research.
Update or confirm your understanding of appropriate clinical nutrition and metabolism practices.
Identify further learning needs as they relate to the subject matter.
Learning Objectives:
Explain how topiramate can serve as an adjunct to lifestyle modification for the treatment of pediatric metabolic dysfunction-associated steatotic liver disease (MASLD)
Describe the potential effects of topiramate on anthropometrics and liver enzymes
Identify which sub-group of patients with pediatric MASLD may most benefit from topiramate use
Summarize safety considerations and monitor for potential side effects from topiramate
Describe standard dosing and upwards titration of topiramate in this clinical context
Requirements for Successful Completion:
To obtain CE credit for this activity, attendees must read the journal article in its entirety, complete an online assessment for each article and achieve a score of 100%, and complete an online activity evaluation. All are located in ASPEN’s eLearning Center (www.nutritioncare.org/elearning). All CE credit must be claimed prior to the expiration date, no exceptions.
ASPEN submits data as required to the CPE Monitor for pharmacists. ASPEN submits physician earned CME credit into Pars. ASPEN does not submit data to any other credentialing organization.
Pharmacists and physicians, please note that ASPEN will upload earned CE credit into the appropriate system within the required timeframe. Any credit not claimed by the deadline will not be entered. Please provide your correct information when completing your evaluation and claiming CE credit. ASPEN submits only the information that is entered by the pharmacist or physician when credit is claimed and is not responsible for following up to obtain any corrected information to ensure an error-free submission.
Associate Professor of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Practice Manager, Connecticut OCD, Anxiety, and Tic Specialists; Research Coordinator, Department of Pediatric Gastroenterology and Liver Transplant, Yale University School of Medicine, New Haven, CT
Assistant Professor, Pediatric Gastroenterology, Hepatology and Nutrition, University of Miami Miller School of Medicine, Jackson Memorial Hospital, Miami, FL
Staff Physician, Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Associate Professor of Clinical Pediatrics (Gastroenterology, Hepatology, and Nutrition), University of Pennsylvania School of Medicine, Philadelphia, PA
Professor of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Accreditation Statement
In support of improving patient care, the American Society for Parenteral and Enteral Nutrition (ASPEN) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
ASPEN designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credits TM per article. Physicians should only claim credit commensurate with the extent of their participation in the activity.
Pharmacists: ASPEN designates this activity for a maximum of 1.0 contact hours/0.1 CEUs. ACPE UAN: JA0002345-0000-25-079-H01-P. Knowledge Activity.
Nurses: ASPEN designates this activity for a maximum of 1.0 nursing contact hours.
Dietitians: ASPEN designates this activity for a maximum of 1.0 CPEUs
This activity was planned by and for the healthcare team, and learners will receive 1 Interprofessional Continuing Education (IPCE) credit for learning and change.
Policies and Information:
Non-Commercialism: ASPEN subscribes to the Standards for Integrity and Independence in Accredited Continuing Education. ASPEN does not provide programs that constitute advertisement or include promotional materials. ASPEN does not endorse any products.
Computer Requirements and Technical Support: Participants will need a computer with internet connection to access the online assessment and evaluation. If the journal article is read electronically, then the ability to read a PDF document is also necessary. Users should enable pop-ups if attempting to read article electronically. For technical difficulties please contact Broadcastmed Customer Support at 1-860-953-2900 or support@broadcastmed.io. Office hours are 8 am – 8 pm ET, Monday–Friday.
Privacy and Confidentiality: ASPEN respects the privacy of its members and website visitors. Companies that receive personal information from ASPEN in order to execute the business of ASPEN may use personal information only for that purpose.
Refund Policy: Refunds are not available.
Grievances: Submit to Senior Director, Education and Research at ASPEN 8401 Colesville Road, Ste 510, Silver Spring, MD 20910
Commercial Support and Sponsorship: None for this activity.
Commercial Relationships Disclosures and Conflicts of Interest (COI) of Authors and Editor-in-Chief and Associate Editors
The following individuals have no financial relationships with ineligible companies: Andrea Tou, Emily Carr, Jennifer Panganiban, Taisa Kohut, Ana Catalina Arce-Clachar
JPEN Deputy and Associate Editors: Bruno A.M.P. Besen, Caitlin Blakeley, Bridget Hron, Diana Mager, Ben Albert, Mark Klang, Jean-Charles Preiser, Jamie Robertson, and Russell de Souza have no financial relationships with ineligible companies.
JPEN EIC: Kenneth Christopher has nothing to disclose.
ASPEN staff have nothing to disclose.
Rima Fawaz: Albireo, hepatic adjudication committee; Mirum, consultant.
Marion Winkler: VectivBio, consultant, Takeda, consultant.
Nicolas Tardif: Fresenius Kabi, research grant, ended.
Annika Reintam Blaser: Nutricia Research Foundation, speaker, ended.
Olav Rooyackers: Baxter, teaching; Fresenius Kabi, consultant; Nestle Healthcare Nutrition, teaching.
Simone CM Silvestre: Danone, speaker.
Ellen Dresen: Bbraun Deutschland, travel, ended; Baxter Deutschland GmbH, speaker, ended; Fresenius Kabi Deutschland GmbH, consultant.
Emma Ridley: Baxter Healthcare US, speaker, research funds, ended; Baxter Healthcare Australia, speaker, ended; Nutricia/Danone Australia, speaker, ended; Fresenius Kabi, speaker, ended; Abbott, consultant, ended.
All relevant financial relationships have been mitigated via the journal peer review process.
Note: an ineligible company is one whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. For specific examples of ineligible companies visit accme.org/standards.
Financial relationships are relevant if the following three conditions are met for the prospective person who will control content of the education:
A financial relationship, in any amount, exists between the person in control of content and an ineligible company.
The financial relationship existed during the past 24 months.
The content of the education is related to the products of an ineligible company with whom the person has a financial relationship.
Read the full article and take the exam for CE credit. This CE activity serves to promote the process of life-long learning for physicians, dietitians, pharmacists, and nurses by providing peer-reviewed journal articles that fully qualify for continuing education credits.
Read the full article and take the exam for CE credit. This CE activity serves to promote the process of life-long learning for physicians, dietitians, pharmacists, and nurses by providing peer-reviewed journal articles that fully qualify for continuing education credits.
Read the full article and take the exam for CE credit. This CE activity serves to promote the process of life-long learning for physicians, dietitians, pharmacists, and nurses by providing peer-reviewed journal articles that fully qualify for continuing education credits.
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