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M10 - Dudrick Symposium: Advances in Preventing Parenteral Nutrition Associated Side Effects (M10)

‐ Mar 22, 2021 10:00am

The 2021 Dudrick Research Symposium: Advances in Preventing Parenteral Nutrition Associated Side Effects, has been planned by the 2020 Stanley J. Dudrick Research Scholar Award winner, Ajay K. Jain, MD, Associate Professor of Pediatrics, St. Louis University, St. Louis, MO.

Parenteral nutrition is the method of providing nutritional needs intravenously. It is lifesaving in clinical settings where adequate enteral delivery of nutrition is not possible. It is used worldwide and remains an essential nutrition delivery strategy in neonates, pediatric and adult patients. However, despite the undeniable benefits of parenteral nutrition, its use is associated with the well characterized, progressive liver injury called intestinal failure associated liver disease. Recent data also demonstrates gut atrophy, gut permeability changes and gut injury with such therapy. Over the past decade there have been significant strides in elucidating mechanisms of parenteral nutrition associated injury and in developing therapeutic strategies.

The Dudrick Symposium aims to provide a comprehensive overview of the current evidence supporting mechanisms of injury associated with parenteral nutrition use and highlight cutting-edge diagnostics, therapeutics, and patient care strategies.

Role of Gut-systemic Signaling in Modulating Parenteral Nutrition Associated Injury
Ajay Jain, MD, DNB, Associate Division Chief; Associate Professor of Pediatrics, Pharmacology and Physiology, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Saint Louis University, St. Louis, MO

Impact of Parenteral Nutrition on the Developing Gut Microbiome

Doug Burrin, PhD; Research Physiologist, USDA-ARS, Children's Nutrition Research Center; Professor of Pediatrics, Baylor College of Medicine, Houston, TX

Intravenous Lipid Emulsions and IFALD - Where We Have Been and Where We Are Going
Manager, Clinical Research, Department of Pharmacy, Boston Children’s Hospital; Assistant Professor of Pediatrics, Harvard Medical School, Boston, MA

Ajay Jain, MD, DNB

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       Ajay K. Jain, MD
 2020 Stanley J. Dudrick 
Research Scholar Award Winner

Learning Objectives:

  • Summarize the current pathophysiology for parenteral nutrition associated injury
  • Describe the role of gut microbiota and lipids in driving injury mechanisms
  • Outline novel diagnostics and biomarkers for estimating the disease burden
  • Describe the role of gut-systemic signaling and novel therapeutic options in mitigating parenteral nutrition associated injury